Impaired insight into illness and cognitive insight in schizophrenia spectrum disorders: resting state functional connectivity.

ABSTRACT:

Background

Impaired insight into illness (clinical insight) in schizophrenia has negative effects on treatment adherence and clinical outcomes. Schizophrenia is described as a disorder of disrupted brain connectivity. In line with this concept, resting state networks (RSNs) appear differentially affected in persons with schizophrenia. Therefore, impaired clinical, or the related construct of cognitive insight (which posits that impaired clinical insight is a function of metacognitive deficits), may reflect alterations in RSN functional connectivity (fc). Based on our previous research, which showed that impaired insight into illness was associated with increased left hemisphere volume relative to right, we hypothesized that impaired clinical insight would be associated with increas

SUBMITTER: Gerretsen P 

PROVIDER: S-EPMC4429527 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature