Impact of precise modulation of reactive oxygen species levels on spermatozoa proteins in infertile men.

ABSTRACT:

Background

Elevated levels of reactive oxygen species (ROS) are detected in 25% to 80% of infertile men. They are involved in the pathology of male infertility. Understanding the effect of increasing levels of ROS on the differential expression of sperm proteins is important to understand the cellular processes and or/pathways that may be implicated in male infertility. The aim of this study was to examine differentially expressed proteins (DEPs) in spermatozoa from patients with low, medium and high ROS levels.

Methods

A total of 42 infertile men presenting for infertility and 17 proven fertile men were enrolled in the study. ROS levels were measured by chemiluminescence assay. Infertile men were divided into Low (0- < 93 RLU/s/10(6) sperm) (n = 11), Medium (>93-500 RLU/s/1

SUBMITTER: Ayaz A 

PROVIDER: S-EPMC4429661 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature