Impact of variability in adherence to HIV antiretroviral therapy on the immunovirological response and mortality.

ABSTRACT:

Background

Several previous studies have shown relationships between adherence to HIV antiretroviral therapy (ART) and the viral load, the CD4 cell count, or mortality. However, the impact of variability in adherence to ART on the immunovirological response does not seem to have been investigated yet.

Methods

Monthly adherence data (November 1999 to April 2009) from 317 HIV-1 infected patients enrolled in the Senegalese ART initiative were analyzed. Latent-class trajectory models were used to build typical trajectories for the average adherence and the standardized variance of adherence. The relationship between the standardized variance of adherence and each of the change in CD4 cell count, the change in viral load, and mortality were investigated using, respectively, a mix

SUBMITTER: Boussari O 

PROVIDER: S-EPMC4429708 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature