Prevalence and Incidence of Respiratory Syncytial Virus and Other Respiratory Viral Infections in Children Aged 6 Months to 10 Years With Influenza-like Illness Enrolled in a Randomized Trial.

ABSTRACT:

Background

The high burden of respiratory syncytial virus (RSV)-associated morbidity and mortality makes vaccine development a priority.

Methods

As part of an efficacy trial of pandemic influenza vaccines (NCT01051661), RSV epidemiology in healthy children aged 6 months to <10 years at first vaccination with influenza-like illness (ILI) was evaluated in Australia, Brazil, Colombia, Costa Rica, Mexico, the Philippines, Singapore, and Thailand between February 2010 and August 2011. Active surveillance for ILI was conducted for approximately 1 year, with nasal and throat swabs analyzed by polymerase chain reaction. The prevalence and incidence of RSV among ILI episodes were calculated.

Results

A total of 6266 children were included, of whom 2421 experienced 3717 ILI epis

SUBMITTER: Nolan T 

PROVIDER: S-EPMC4429758 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature