Persistent organic pollutants in young adults and changes in glucose related metabolism over a 23-year follow-up.

ABSTRACT:

Objectives

Substantial evidence associates persistent organic pollutants (POP) with metabolic disturbances related to diabetes, but longitudinal studies with repeated measures are scarce. We aimed to characterize the association between background exposures to POPs with repeated measures of glucose homeostasis over 23-years.

Methods

Within the Coronary Artery Risk Development in Young Adults study (year 0 ages: 18-30 years), we measured POPs in serum obtained in 1987-88 (follow-up year 2) in 90 non-diabetic controls and 90 cases diabetes-free at year 2 who became diabetic by year 20. We analyzed 32 POPs detectable in ≥75% of participants and created summary scores for 32 POPs, 23 polychlorinated biphenyls (PCB), and 8 organochlorine pesticides (OCP). Dependent variables were

SUBMITTER: Suarez-Lopez JR 

PROVIDER: S-EPMC4429782 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature