Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants.

ABSTRACT:

Background

Extremely preterm birth is associated with subsequent behavioral problems. We hypothesized that perinatal systemic inflammation, a risk factor for cerebral white matter injury and cognitive impairment, is associated with behavior problems observed at 2 y.

Methods

In a cohort of 600 children born before 28 wk gestation, we measured 25 inflammation-related proteins in blood collected on postnatal days 1, 7, and 14, and identified behavior problems using parent responses to the Child Behavior Checklist for Ages 1.5-5 (CBCL/1.5-5) at 2 y of age. A persistent or recurrent protein elevation was defined as a concentration in the highest quartile (for gestational age and postnatal age) on at least 2 d ~1 wk apart. Behavior problems were defined by CBCL/1.5-5 subscale scor

SUBMITTER: O'Shea TM 

PROVIDER: S-EPMC4429865 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature