NF-κB and IRF pathways: cross-regulation on target genes promoter level.

ABSTRACT:

Background

The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known.

Results

Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. These findings agree with recent experimental data reporting crosstalk between pathways activated by RIG-I and TLR3 receptors in response to pathogens.

Conclusions

We present an extended crosstalk diagram of the IRF - N

SUBMITTER: Iwanaszko M 

PROVIDER: S-EPMC4430024 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature