The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex.

ABSTRACT:

Background

Mild hypothermia may be frequently induced due to cool environments in the operating room. The study analyzed patient recovery time and response to sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) during mild hypothermia.

Methods

Sixty patients were randomly (1:1) allocated to the mild hypothermia and normothermia groups, defined as having core temperatures between 34.5-35°C and 36.5-37°C, respectively. Patients received 0.6 mg/kg of rocuronium, followed by 7-10 μg/kg/min to maintain a deep NMB [post-tetanic count (PTC) 1-2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. The primary end-point was the time until the train-of-four (TOF) ratio was 0.9.

Results

The appropriate neuromuscular function (TOF ratio

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC4430027 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature