Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups.

Methods

We estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476 AFA and HA women from the Women's Health Initiative. Cox regression models were used to examine the association between admixture and diabetes risk, with and without accounting for socioeconomic status (SES) and adiposity measurements.

Results

AFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age, neighbourhood SES and BMI or

SUBMITTER: Qi L 

PROVIDER: S-EPMC4430092 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature