Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study.

ABSTRACT:

Objective

To evaluate maternal medical and perinatal outcomes associated with antipsychotic drug use in pregnancy.

Design

High dimensional propensity score (HDPS) matched cohort study.

Setting

Multiple linked population health administrative databases in the entire province of Ontario, Canada.

Participants

Among women who delivered a singleton infant between 2003 and 2012, and who were eligible for provincially funded drug coverage, those with ≥ 2 consecutive prescriptions for an antipsychotic medication during pregnancy, at least one of which was filled in the first or second trimester, were selected. Of these antipsychotic drug users, 1021 were matched 1:1 with 1021 non-users by means of a HDPS algorithm.

Main outcome measures

The main maternal medical

SUBMITTER: Vigod SN 

PROVIDER: S-EPMC4430156 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature