Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.

ABSTRACT:

Purpose

To monitor retinal pigment epithelial (RPE) atrophy progression during antiangiogenic therapy of neovascular age-related macular degeneration (AMD) over 2 years using polarization-sensitive optical coherence tomography (OCT).

Design

Prospective interventional case series.

Methods

setting: Clinical practice.

Study population

Thirty patients (31 eyes) with treatment-naïve neovascular AMD.

Observation procedures

Standard intravitreal therapy (0.5 mg ranibizumab) was administered monthly during the first year and pro re nata (PRN; as-needed) during the second year. Spectral-domain (SD) OCT and polarization-sensitive OCT (selectively imaging the RPE) examinations were performed at baseline and at 1, 3, 6, 12, and 24 months using a standardized protoco

SUBMITTER: Schutze C 

PROVIDER: S-EPMC4430174 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature