The winding road to regenerating the human heart.

ABSTRACT:

Unlabelled

Regenerating the human heart is a challenge that has engaged researchers and clinicians around the globe for nearly a century. From the repair of the first septal defect in 1953, followed by the first successful heart transplant in 1967, and later to the first infusion of bone marrow-derived cells to the human myocardium in 2002, significant progress has been made in heart repair. However, chronic heart failure remains a leading pathological burden worldwide. Why has regenerating the human heart been such a challenge, and how close are we to achieving clinically relevant regeneration? Exciting progress has been made to establish cell transplantation techniques in recent years, and new preclinical studies in large animal models have shed light on the promises and challeng

SUBMITTER: Gerbin KA 

PROVIDER: S-EPMC4430350 | biostudies-literature | 2015 May-Jun

REPOSITORIES: biostudies-literature