An exploratory short-term double-blind randomized trial of varenicline versus nicotine patch for smoking cessation in women.

ABSTRACT:

Aims

Within a parent study examining ovarian hormone effects on smoking cessation in women, we conducted an exploratory short-term trial of varenicline versus transdermal nicotine patch.

Design

Double-blind double-dummy randomized trial.

Setting

Single-site out-patient research clinic in the United States.

Participants

Female smokers, ages 18-45 years and averaging ≥10 cigarettes per day for at least 6 months (n=140).

Interventions

Participants were randomized to receive a 4-week course of (a) varenicline tablets and placebo patches (n = 67) or (b) placebo tablets and nicotine patches (n=73). Two brief cessation counseling sessions were provided for all participants.

Measurements

The outcome of primary clinical interest was 2-week end-of-treatment

SUBMITTER: Gray KM 

PROVIDER: S-EPMC4430389 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature