Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore.

ABSTRACT:

Background

Opening of the mitochondrial permeability transition pore is the underlying cause of cellular dysfunction during diverse pathological situations. Although this bioenergetic entity has been studied extensively, its molecular componentry is constantly debated. Cyclophilin D is the only universally accepted modulator of this channel and its selective ligands have been proposed as therapeutic agents with the potential to regulate pore opening during disease.

Scope of review

This review aims to recapitulate known molecular determinants necessary for Cyclophilin D activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore.

Major conclusions

While the main target of Cyclophilin D is still a matte

SUBMITTER: Gutierrez-Aguilar M 

PROVIDER: S-EPMC4430462 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature