Immunosuppressive therapy in patients with aplastic anemia: a single-center retrospective study.

ABSTRACT:

Background

Aplastic anemia (AA) is a rare disease in which hematopoietic stem cells are severely diminished resulting in hypocellular bone marrow and pancytopenia. Etiology of AA includes auto immunity, toxins, infection, ionizing radiation, drugs and rare genetic disorders, but in the majority of cases no cause can be identified. In the present study we assessed response rate, survival, relapse and clonal evolution in patients with AA treated with immunosuppressive therapy.

Methods

Patients with AA who received immunosuppressive therapy between May 1998 and September 2013 were included in this study. Patients with non-severe AA (NSAA) were treated with cyclosporine (CsA) and danazol while patients with severe AA (SAA) as well as patients with NSAA who progressed to SAA afte

SUBMITTER: Jalaeikhoo H 

PROVIDER: S-EPMC4430492 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature