Membrane capacitive memory alters spiking in neurons described by the fractional-order Hodgkin-Huxley model.

ABSTRACT: Excitable cells and cell membranes are often modeled by the simple yet elegant parallel resistor-capacitor circuit. However, studies have shown that the passive properties of membranes may be more appropriately modeled with a non-ideal capacitor, in which the current-voltage relationship is given by a fractional-order derivative. Fractional-order membrane potential dynamics introduce capacitive memory effects, i.e., dynamics are influenced by a weighted sum of the membrane potential prior history. However, it is not clear to what extent fractional-order dynamics may alter the properties of active excitable cells. In this study, we investigate the spiking properties of the neuronal membrane patch, nerve axon, and neural networks described by the fractional-order Hodgkin-Huxley neuron model.

SUBMITTER: Weinberg SH 

PROVIDER: S-EPMC4430543 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature