Inter-individual variation in morphine clearance in children.

ABSTRACT:

Objectives

The aim of the study was to determine the extent of inter-individual variation in clearance of intravenous morphine in children and to establish which factors are responsible for this variation.

Methods

A systematic literature review was performed to identify papers describing the clearance of morphine in children. The following databases were searched: Medline, Embase, International Pharmaceutical Abstracts, CINAHL, and Cochrane library. From the papers, the range in plasma clearance and the coefficient of variation (CV) in plasma clearance were determined.

Results

Twenty-eight studies were identified. After quality assessment, 20 studies were included. Only 10 studies gave clearance values for individual patients. The majority of the studies were in criti

SUBMITTER: Altamimi MI 

PROVIDER: S-EPMC4430598 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature