DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer.

ABSTRACT:

Background

Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy assessment in hysterectomy specimens is a well-established prognostic marker. DNA ploidy assessment in preoperative curettage specimens is less studied, and in particular in relation to the occurrence of lymph node metastasis.

Methods

Curettage image cytometry DNA ploidy in relation to established clinicopathological variables and outcome was investigated in 785 endometrial carcinoma patients prospectively included in the MoMaTEC multicentre trial.

Results

Diploid curettage status was found in 72.0%, whereas 28.0% were non-diploid. Non-diploid status signi

SUBMITTER: Njolstad TS 

PROVIDER: S-EPMC4430715 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature