Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.

ABSTRACT:

Objectives

Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions remain high-priority knowledge gaps. We sought to identify novel common genetic variants associated with perioperative MI in patients undergoing coronary artery bypass grafting using genome-wide association methodology.

Setting

107 secondary and tertiary cardiac surgery centres across the USA.

Participants

We conducted a stage I genome-wide association study (GWAS) in 1433 ethnically diverse patients of both genders (112 cases/1321 controls) from the Genetics of Myocardial Adverse Outcomes and Graft Failure (GeneMAGIC) study, and a stage II an

SUBMITTER: Kertai MD 

PROVIDER: S-EPMC4431169 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature