Pretreatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial.

ABSTRACT:

Objectives

Prediction of radiographic progression (RP) in early rheumatoid arthritis (eRA) would be very useful for optimal choice among available therapies. We evaluated a multi-biomarker disease activity (MBDA) score, based on 12 serum biomarkers as a baseline predictor for 1-year RP in eRA.

Methods

Baseline disease activity score based on erythrocyte sedimentation rate (DAS28-ESR), disease activity score based on C-reactive protein (DAS28-CRP), CRP, MBDA scores and DAS28-ESR at 3 months were analysed for 235 patients with eRA from the Swedish Farmacotherapy (SWEFOT) clinical trial. RP was defined as an increase in the Van der Heijde-modified Sharp score by more than five points over 1 year. Associations between baseline disease activity measures, the MBDA score, and 1-yea

SUBMITTER: Hambardzumyan K 

PROVIDER: S-EPMC4431327 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature