The " NF-ĸ B interacting long noncoding RNA" ( NKILA) transcript is antisense to cancer-associated gene PMEPA1.

ABSTRACT: This correspondence concerns a recent publication in Cancer Cell by Liu et al. (1) who analyzed a long noncoding RNA (lncRNA) that they designated " NKILA". Liu et al. found that NKILA (1)  is upregulated by immunostimulants, (2) has a promoter with an NF-ĸB binding motif, (3) can bind to the p65 protein of the NF-ĸB transcription factor and then interfere with phosphorylation of IĸBα, and (4) negatively affects functions that involve NF-ĸB pathways.  And, importantly, they found that (5) low NKILA expression in breast cancers is associated with poor patient prognosis.  However, they entirely failed to mention PMEPA1, a gene which runs antisense to NKILA, and the expression of which is associated with several tumors and which encodes a protein that participates in immune pathways. The PMEP

SUBMITTER: Dijkstra JM 

PROVIDER: S-EPMC4431381 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature