A controllable aptamer-based self-assembled DNA dendrimer for high affinity targeting, bioimaging and drug delivery.

ABSTRACT: Targeted drug delivery is important in cancer therapy to decrease the systemic toxicity resulting from nonspecific drug distribution and to enhance drug delivery efficiency. We have developed an aptamer-based DNA dendritic nanostructure as a multifunctional vehicle for targeted cancer cell imaging and drug delivery. The multifunctional DNA dendrimer is constructed from functional Y-shaped building blocks with predesigned base-pairing hybridization including fluorophores, targeting DNA aptamers and intercalated anticancer drugs. With controllable step-by-step self-assembly, the programmable DNA dendrimer has several appealing features, including facile modular design, excellent biostability and biocompatibility, high selectivity, strong binding affinity, good cell internalization efficiency

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4431499 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature