Central and peripheral irisin differentially regulate blood pressure.

ABSTRACT:

Introduction

Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown.

Purpose

To explore the effects of central and peripheral irisin on cardiovascular functions.

Methods

Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured.

Results

Administration of recombinant human irisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibi

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4431576 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature