Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder.

ABSTRACT:

Background

The genetic architecture of ADHD is complex, with rare and common variants involved. Common genetic variants (as indexed by a composite risk score) associated with clinical ADHD significantly predict ADHD and autistic-like behavioural traits in children from the general population, suggesting that ADHD lies at the extreme of normal trait variation. ADHD and other neurodevelopmental disorders share neurocognitive difficulties in several domains (e.g. impaired cognitive ability and executive functions). We hypothesised that ADHD composite genetic risk scores derived from clinical ADHD cases would also contribute to variation in neurocognitive abilities in the general population.

Methods

Children (N = 6,832) from a UK population cohort, the Avon Longitudinal Study of

SUBMITTER: Martin J 

PROVIDER: S-EPMC4431584 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature