Platelet membrane variations and their effects on δ-granule secretion kinetics and aggregation spreading among different species.

ABSTRACT: Platelet exocytosis is regulated partially by the granular/cellular membrane lipids and proteins. Some platelets contain a membrane-bound tube, called an open canalicular system (OCS), which assists in granular release events and increases the membrane surface area for greater spreading. The OCS is not found in all species, and variations in membrane composition can cause changes in platelet secretion. Since platelet studies use various animal models, it is important to understand how platelets differ in both their composition and granular release to draw conclusions among various models. The relative phospholipid composition of the platelets with (mouse, rabbit) and without (cow) an OCS was quantified using UPLC-MS/MS. Cholesterol and protein composition was measured using an Amplex Red A

SUBMITTER: Gruba SM 

PROVIDER: S-EPMC4431631 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature