Topiramate for cocaine dependence during methadone maintenance treatment: a randomized controlled trial.

ABSTRACT:

Background

Dual dependence on opiate and cocaine occurs in about 60% of patients admitted to methadone maintenance and negatively impacts prognosis (Kosten et al. 2003. Drug Alcohol Depend. 70, 315). Topiramate (TOP) is an antiepileptic drug that may have utility in the treatment of cocaine dependence because it enhances the GABAergic system, antagonizes the glutamatergic system, and has been identified by NIDA as one of only a few medications providing a "positive signal" warranting further clinical investigation. (Vocci and Ling, 2005. Pharmacol. Ther. 108, 94).

Method

In this double-blind controlled clinical trial, cocaine dependent methadone maintenance patients (N=171) were randomly assigned to one of four groups. Under a factorial design, participants received either T

SUBMITTER: Umbricht A 

PROVIDER: S-EPMC4431633 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature