Emerging translational approaches to target STAT3 signalling and its impact on vascular disease.

ABSTRACT: Acute and chronic inflammation responses characterize the vascular remodelling processes in atherosclerosis, restenosis, pulmonary arterial hypertension, and angiogenesis. The functional and phenotypic changes in diverse vascular cell types are mediated by complex signalling cascades that initiate and control genetic reprogramming. The signalling molecule's signal transducer and activator of transcription 3 (STAT3) plays a key role in the initiation and continuation of these pathophysiological changes. This review highlights the pivotal involvement of STAT3 in pathological vascular remodelling processes and discusses potential translational therapies, which target STAT3 signalling, to prevent and treat cardiovascular diseases. Moreover, current clinical trials using highly effective and se

SUBMITTER: Dutzmann J 

PROVIDER: S-EPMC4431663 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature