A genome scan for loci shared by autism spectrum disorder and language impairment.

ABSTRACT:

Objective

The authors conducted a genetic linkage study of families that have both autism spectrum disorder (ASD) and language-impaired probands to find common communication impairment loci. The hypothesis was that these families have a high genetic loading for impairments in language ability, thus influencing the language and communication deficits of the family members with ASD. Comprehensive behavioral phenotyping of the families also enabled linkage analysis of quantitative measures, including normal, subclinical, and disordered variation in all family members for the three general autism symptom domains: social, communication, and compulsive behaviors.

Method

The primary linkage analysis coded persons with either ASD or specific language impairment as "affected." The se

SUBMITTER: Bartlett CW 

PROVIDER: S-EPMC4431698 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature