Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction.

ABSTRACT: Mental stress induced left ventricular dysfunction (LVD) has been associated with a greater risk of adverse events in coronary heart disease (CHD) patients independent of conventional risk indicators. The underlying biochemical mechanisms of this cardiovascular condition are poorly understood. Our objective was to use metabolomics technology to identify biochemical changes that co-occur with mental stress-induced LVD in patients with clinically stable CHD. Participants were adult CHD patients who were recruited for mental stress-induced myocardial ischemia screening. For this study, we randomly selected 30 patients representing the extremes of the mental stress-induced left ventricular ejection fraction (LVEF) change distribution; 15 who showed LVD (i.e. LVEF reduction ≥5) and 15 who showe

SUBMITTER: Boyle SH 

PROVIDER: S-EPMC4431771 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature