Congenital anomalies in children exposed to antithyroid drugs in-utero: a meta-analysis of cohort studies.

ABSTRACT:

Background

Hyperthyroidism affects about 0.2%-2.7% of all pregnancies, and is commonly managed with antithyroid drugs (ATDs). However, previous studies about the effects of ATDs on congenital anomalies are controversial. Therefore, the present meta-analysis was performed to explore the risk of congenital anomalies in children exposed to ATDs in-utero.

Methods

Embase, Pubmed, Web of Knowledge, and BIOSIS Citation Index were searched to find out studies about congenital anomalies in children exposed to ATDs in-utero reported up to May 2014. The references cited by the retrieved articles were also searched. The relative risks (RRs) and confidence intervals (CIs) for the individual studies were pooled by fixed effects models, and heterogeneity was analyzed by chi-square and I2 t

SUBMITTER: Li H 

PROVIDER: S-EPMC4431808 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature