A draft map of rhesus monkey tissue proteome for biomedical research.

ABSTRACT: Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains challenging due to the lack of a complete protein sequence database and effective strategy. To investigate the most effective and high-throughput proteomic strategy, comparative data analysis was performed employing various protein databases and search engines. The UniProt databases of monkey, human, bovine, rat and mouse were used for the comparative analysis and also a universal database with all protein sequences from all available species was tested. At the same time, de novo sequencing was compared to the SEQUEST search algorithm to identif

SUBMITTER: Lee JG 

PROVIDER: S-EPMC4431823 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature