Incidence of Cancer in ANCA-Associated Vasculitis: A Meta-Analysis of Observational Studies.

ABSTRACT:

Objective

The purpose of this paper is to examine cancer incidence in patients with ANCA-associated vasculitis (AASV) derived from population-based cohort studies by means of meta-analysis.

Methods

Relevant electronic databases were searched for studies characterizing the associated risk of overall malignancy in patients with AASV. Standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were used to evaluate the strength of association. We tested for publication bias and heterogeneity and stratified for site-specific cancers.

Results

Six studies (n = 2,578) were eventually identified, of which six provided the SIR for overall malignancy, five reported the SIR for non-melanoma skin cancer (NMSC), four for leukemia, five for bladder cancer, three for lym

SUBMITTER: Shang W 

PROVIDER: S-EPMC4431871 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature