Identification of target proteins involved in cochlear otosclerosis.

ABSTRACT:

Hypothesis

Investigation of differential protein expression will provide clues to pathophysiology in otosclerosis.

Background

Otosclerosis is a bone remodeling disorder limited to the endochondral layer of the otic capsule within the temporal bone. Some authors have suggested an inflammatory etiology for otosclerosis resulting from persistent measles virus infection involving the otic capsule. Despite numerous genetic studies, implication of candidate genes in the otosclerotic process remains elusive. We employed liquid chromatography-mass spectrometry (LC-MS) analysis on formalin-fixed celloidin-embedded temporal bone tissues for postmortem investigation of otosclerosis.

Methods

Proteomic analysis was performed using human temporal bones from a patient with severe ot

SUBMITTER: Richard C 

PROVIDER: S-EPMC4431897 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature