Ontology highlight
ABSTRACT:
SUBMITTER: Aird KM
PROVIDER: S-EPMC4431925 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Aird Katherine M KM Worth Andrew J AJ Snyder Nathaniel W NW Lee Joyce V JV Sivanand Sharanya S Liu Qin Q Blair Ian A IA Wellen Kathryn E KE Zhang Rugang R
Cell reports 20150430 6
Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor-suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic reprogramming. However, the role of metabolic reprogramming in the cellular response to replication stress has been little explored. Here, we report that ataxia telangiectasia mutated (ATM) plays a c ...[more]