Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients.

ABSTRACT:

Background

Studies of symptomatic gastroparetics consistently find poor correlation with gastric emptying. We hypothesized that concomitant small bowel dysmotility may play a role in symptom causation in gastroparesis and sought to test this hypothesis by using wireless motility capsule (WMC) testing to simultaneously measure antral and duodenal area under pressure curve (AUC) in patients with delayed gastric emptying.

Methods

Using a cohort from a multicenter clinical trial and a separate tertiary clinical database, we identified gastroparetics that underwent concurrent WMC testing and completed the Gastroparesis Cardinal Symptom Index, a validated questionnaire. Our study included 35 gastroparetics defined by a gastric emptying time (GET) ≥ 5 h. Antral and duodenal AUC wer

SUBMITTER: Barshop K 

PROVIDER: S-EPMC4432031 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature