BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R.

ABSTRACT:

Background

B cell activating factor belonging to the TNF family (BAFF) is vital for B cell survival, proliferation and activation. Evidence indicates that BAFF is systemically or locally increased in glomerulonephritis (e.g. lupus nephritis, IgA nephropathy). However, the effect of BAFF on human mesangial cells is not known.

Methods

The impact of BAFF on the proliferation of a human mesangial cell line in vitro was investigated. The expression of BAFF receptor (BAFF-R) and downstream signal transduction were explored. The influence of BAFF on the expression of related genes was also studied.

Results

Our data indicated that BAFF had a proliferative effect on human mesangial cells, as supported by the results of cell proliferation assays and the inhibited expression of

SUBMITTER: Zheng N 

PROVIDER: S-EPMC4432501 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature