Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles-A longitudinal MRI study of 76 middle-aged and older adults.

ABSTRACT: Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal areas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions [3D T1-weighted and diffusion weighted imaging (DWI)] were obtained from healthy older adults (N = 76, range 49-80 years at inclusion) at two time points, 3 years apart. A subset of the participants (N = 24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean

SUBMITTER: Vik A 

PROVIDER: S-EPMC4432666 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature