Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin.

ABSTRACT: The intestinal barrier controls the balance between tolerance and immunity to luminal antigens. When this finely tuned equilibrium is deregulated, inflammatory disorders can occur. There is a concomitant increase, in urban populations of developed countries, of immune-mediated diseases along with a shift in Escherichia coli population from the declining phylogenetic group A to the newly dominant group B2, including commensal strains producing a genotoxin called colibactin that massively colonized the gut of neonates. Here, we showed that mother-to-offspring early gut colonization by colibactin-producing E. coli impairs intestinal permeability and enhances the transepithelial passage of luminal antigen, leading to an increased immune activation. Functionally, this was accompanied by a drama

SUBMITTER: Secher T 

PROVIDER: S-EPMC4432747 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature