Bistable expression of CsgD in Salmonella enterica serovar Typhimurium connects virulence to persistence.

ABSTRACT: Pathogenic bacteria often need to survive in the host and the environment, and it is not well understood how cells transition between these equally challenging situations. For the human and animal pathogen Salmonella enterica serovar Typhimurium, biofilm formation is correlated with persistence outside a host, but the connection to virulence is unknown. In this study, we analyzed multicellular-aggregate and planktonic-cell subpopulations that coexist when S. Typhimurium is grown under biofilm-inducing conditions. These cell types arise due to bistable expression of CsgD, the central biofilm regulator. Despite being exposed to the same stresses, the two cell subpopulations had 1,856 genes that were differentially expressed, as determined by transcriptome sequencing (RNA-seq). Aggregated cel

SUBMITTER: MacKenzie KD 

PROVIDER: S-EPMC4432751 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature