Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure.

ABSTRACT:

Background

Heart failure (HF) is the most common cause of morbidity and mortality in developed countries. Here, we identify biologically relevant transcripts that are significantly altered in the early phase of myocardial infarction and are associated with the development of post-myocardial infarction HF.

Methods

We collected peripheral blood samples from patients with ST-segment elevation myocardial infarction (STEMI): n = 111 and n = 41 patients from the study and validation groups, respectively. Control groups comprised patients with a stable coronary artery disease and without a history of myocardial infarction. Based on plasma NT-proBNP level and left ventricular ejection fraction parameters the STEMI patients were divided into HF and non-HF groups. Microarrays were use

SUBMITTER: Maciejak A 

PROVIDER: S-EPMC4432772 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature