The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the Chr9p21 region are associated with coronary artery disease (CAD). Most of the SNPs identified in this region are non-coding SNPs, suggesting that they may influence gene expression by cis or trans mechanisms to affect disease susceptibility. Since all cells from an individual have the same DNA sequence variations, levels of gene expression in immortalized cell lines can reflect the functional effects of DNA sequence variations that influence or regulate gene expression. The objective of this study is to evaluate the functional consequences of the risk variants in the Chr9p21 region on gene expression.

Methods

We examined the association between the variants

SUBMITTER: Zhao W 

PROVIDER: S-EPMC4432789 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature