Effects of methamphetamine on the noradrenergic activity biomarker salivary alpha-amylase.

ABSTRACT:

Background

Methamphetamine (METH) potently activates the sympathetic nervous system (SNS) by increasing central and peripheral norepinephrine (NE). Salivary α-amylase (sAA) is a biomarker of SNS activation that correlates with plasma NE levels. The purpose of this study was to determine the impact of METH on sAA activity and whether changes in sAA activity were correlated with subjective effects ratings.

Methods

Non-treatment seeking METH-dependent volunteers (N=8) participated in this within-subjects laboratory-based study. Volunteers received randomly administered intravenous METH (0mg, 30 mg) and sAA activity, cardiovascular measures and subjective ratings were assessed at baseline (-15 min) and five post-METH time points (10, 20, 30, 45, and 60 min).

Results

METH

SUBMITTER: Haile CN 

PROVIDER: S-EPMC4432865 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature