LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia.

ABSTRACT:

Unlabelled

Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is unknown. Therefore, unbiased microarray profiling was performed on human B-ALL specimens, and it was determined that lncRNA expression correlates with cytogenetic abnormalities, which was confirmed by qRT-PCR in a large set of B-ALL cases. Importantly, high expression of BALR-2 correlated with poor overall survival and diminished response to prednisone treatment. In line with a function for this lncRNA in regulating cell survival, BALR-2 knockdown led to reduced proliferation, increased apoptosis, and increased sensitivity to prednisolo

SUBMITTER: Fernando TR 

PROVIDER: S-EPMC4433429 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature