Effect of white matter lesions on manual dexterity in healthy middle-aged persons.

ABSTRACT:

Objectives

We hypothesized that integrated motor-visual functions measured by manipulative manual dexterity are affected by white matter lesion (WML) burden as measured on cranial MRI across relevant brain regions in subjects at risk of preclinical occult vascular disease.

Methods

A real-time cross-sectional study of healthy subjects aged 29 to 74 years with a family history of early-onset coronary artery disease (n = 714; mean age, 51 ± 11 years; mean education, 14 ± 3 years; 42% male; 38% black) were identified from probands with coronary artery disease diagnosed before age 60 years. WMLs on 3-tesla brain MRI and Grooved Pegboard scores were measured.

Results

WMLs were observed at all ages. Mean pegboard scores were 108 ± 18, similar to normal populations. In unadju

SUBMITTER: Nyquist PA 

PROVIDER: S-EPMC4433457 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature