Risk and protective factors for cognitive impairment in persons aged 85 years and older.

ABSTRACT:

Objective

To determine risk and protective factors for mild cognitive impairment (MCI) among persons 85 years and older.

Methods

Participants in the population-based prospective Mayo Clinic Study of Aging were comprehensively evaluated at baseline and at 15 monthly intervals to determine incident MCI. At baseline, lifestyle factors in midlife and late life were assessed by self-reported questionnaire; vascular and comorbid conditions were abstracted from participants' medical records.

Results

Of 256 participants who were cognitively normal at enrollment (median age 87.3 years, 62% women), 121 developed MCI at a median 4.1 years of follow-up. Predictors of MCI were APOE ε4 allele (hazard ratio [HR] 1.89; p = 0.008), current depressive symptoms (HR 1.78; p = 0.02), midl

SUBMITTER: Roberts RO 

PROVIDER: S-EPMC4433468 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature