Characteristics of Bipolar I patients grouped by externalizing disorders.

ABSTRACT:

Background

Bipolar disorder co-occurs with a number of disorders with externalizing features. The aim of this study is to determine whether Bipolar I (BPI) subjects with comorbid externalizing disorders and a subgroup with externalizing symptoms prior to age 15 have different clinical features than those without externalizing disorders and whether these could be attributed to specific genetic variations.

Methods

A large cohort (N=2505) of Bipolar I subjects was analyzed. Course of illness parameters were compared between an Externalizing Group, an Early-Onset Subgroup and a Non-Externalizing Group in the Discovery sample (N=1268). Findings were validated using an independent set of 1237 BPI subjects (Validation sample). Genetic analyses were carried out.

Results

Subje

SUBMITTER: Swaminathan S 

PROVIDER: S-EPMC4433475 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature