Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization.

ABSTRACT:

Rationale

Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularly important for their expression. However, there is a weak understanding of the changes in neural firing and oscillatory activity in the PFC evoked by repeated drug use, thus complicating the development of novel treatment strategies for addiction.

Objectives

The purpose of the current study was to assess changes in cognitive and brain function following MA sensitization.

Methods

Sensitization was induced in rats, then temporal and recognition memory wer

SUBMITTER: Janetsian SS 

PROVIDER: S-EPMC4433565 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature