Structure-based functional annotation of putative conserved proteins having lyase activity from Haemophilus influenzae.

ABSTRACT: Haemophilus influenzae is a small pleomorphic Gram-negative bacteria which causes several chronic diseases, including bacteremia, meningitis, cellulitis, epiglottitis, septic arthritis, pneumonia, and empyema. Here we extensively analyzed the sequenced genome of H. influenzae strain Rd KW20 using protein family databases, protein structure prediction, pathways and genome context methods to assign a precise function to proteins whose functions are unknown. These proteins are termed as hypothetical proteins (HPs), for which no experimental information is available. Function prediction of these proteins would surely be supportive to precisely understand the biochemical pathways and mechanism of pathogenesis of Haemophilus influenzae. During the extensive analysis of H. influenzae genome, we f

SUBMITTER: Shahbaaz M 

PROVIDER: S-EPMC4434415 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature