Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice.

ABSTRACT:

Background

Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we assessed the contributions of both estradiol and sex chromosome complement on Gh mRNA levels in three large brain regions: the hippocampus, hypothalamus, and cerebellum.

Methods

We used th

SUBMITTER: Quinnies KM 

PROVIDER: S-EPMC4434521 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature