Home Circadian Phase Assessments with Measures of Compliance Yield Accurate Dim Light Melatonin Onsets.

ABSTRACT:

Study objectives

There is a need for the accurate assessment of circadian phase outside of the clinic/laboratory, particularly with the gold standard dim light melatonin onset (DLMO). We tested a novel kit designed to assist in saliva sampling at home for later determination of the DLMO. The home kit includes objective measures of compliance to the requirements for dim light and half-hourly saliva sampling.

Design

Participants were randomized to one of two 10-day protocols. Each protocol consisted of two back-to-back home and laboratory phase assessments in counterbalanced order, separated by a 5-day break.

Setting

Laboratory or participants' homes.

Participants

Thirty-five healthy adults, age 21-62 y.

Interventions

N/A.

Measurements and results

M

SUBMITTER: Burgess HJ 

PROVIDER: S-EPMC4434555 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature